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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 35-40 doi: 10.1007/s11684-012-0171-0
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
关键词: α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
单萜类化合物芳樟醇、甲基丁香酚、草蒿脑和香茅醛对配体门控离子通道的作用模式 Article
Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen
《工程(英文)》 2020年 第6卷 第5期 页码 541-545 doi: 10.1016/j.eng.2019.07.027
在传统的医学治疗中,精油被用作镇静剂、抗惊厥剂以及局部麻醉剂,还可以用作储藏食品、水果、蔬菜和谷物等的防腐剂,同时,它还能用作食品生产的生物农药。芳樟醇(LL)以及其他一些主要组分,如甲基丁香酚(ME)、草蒿脑(EG)和香茅醛是许多精油(如罗勒精油)中的活性化学成分。罗勒精油以及上述单萜类化合物在驱除害虫等方面有明显的功效。然而,这些化学成分的作用机制尚不明确。众所周知,γ-氨基丁酸A型受体(GABAAR)和烟碱型乙酰胆碱受体(nAChR)是目前市场上使用的合成杀虫剂的主要分子靶标。此外,GABAAR靶向治疗也已经有了数十年的临床应用实践,如巴比妥类药物和苯二氮类药物。在本研究中,我们研究了LL、ME、EG和香茅醛对GABAAR和nAChR的电生理作用,以进一步了解它们作为传统药物治疗剂和杀虫剂的多功能性。研究结果表明,LL对GABAAR和nAChR均有抑制作用,这或许可以解释LL的杀虫活性。LL是GABAAR的一种浓度依赖性、非竞争性抑制剂,因为在实验中我们发现,小鼠α1β3γ2L GABAAR的γ-氨基丁酸(GABA)半最大效应浓度(EC50)值不受LL影响:在LL不存在或存在5 mmol·L–1 LL的情况下,该半最大效应浓度值分别为(36.2 ± 7.9) μmol·L–1以及(36.1 ± 23.8) μmol·L–1。LL对GABAAR的半抑制浓度(IC50)约为3.2 mmol·L–1。考虑到在精油之中存在着多种单萜类化合物,所以LL可能与此前被表征为GABAAR激动剂和正变构调节物的ME以及其他单萜类化合物具有协同作用,这为LL的镇静、抗惊厥效用和杀虫活性提供了一种可能的解释。
关键词: 精油 γ-氨基丁酸A型受体 芳樟醇 单萜 烟碱型乙酰胆碱受体
Resistance of large deformation of the Wushaoling Tunnel F7 soft fault
ZHAO Xufeng, CHEN Haiming, WANG Chunmiao
《结构与土木工程前沿(英文)》 2007年 第1卷 第1期 页码 123-127 doi: 10.1007/s11709-007-0013-3
Acid Orange 7 degradation using methane as the sole carbon source and electron donor
《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1468-5
• AO7 degradation was coupled with anaerobic methane oxidation.
关键词: Azo dyes AO7 degradation Anaerobic methane oxidation Microbial community ANME-2d
《环境科学与工程前沿(英文)》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1604-5
● Metabolomic temporal profiling of cells exposed to xenobiotics.
关键词: Metabolomics BPA MCF-7 Temporal profiling Metabolic adaption Dysregulation correlation
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 8-20 doi: 10.1007/s11684-020-0739-z
A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO
Jing DONG, Huilong WANG
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 245-251 doi: 10.1007/s11705-010-1003-x
关键词:
chlorine dioxide
2
6-dinitro-
Erratum to “After Highflyer Crashes, Airborne Wind Energy Regroups” [Engineering 7 (2021) 277–279]
Peter Weiss
《工程(英文)》 2021年 第7卷 第10期 页码 1506-1506 doi: 10.1016/j.eng.2021.08.004
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《医学前沿(英文)》 2015年 第9卷 第2期 页码 134-138 doi: 10.1007/s11684-015-0396-9
Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on bypass track resistance, which involves the activation of alternate signaling molecules by tumor cells to bypass inhibition and maintain signaling output, and consider the problems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.
关键词: targeted therapy drug resistance receptor tyrosine kinases cancer
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 471-479 doi: 10.1007/s11684-017-0602-z
Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutinin stalk domain are in development. Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with little to no cross-group reactivity and protection. Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1 or group 2 hemagglutinins with very few that bind to hemagglutinins of both groups. Here we review what is known about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses on a polyclonal and monoclonal level. It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses. A better understanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus vaccine candidates.
关键词: universal influenza virus vaccine hemagglutinin stalk H7N9
Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 275-276 doi: 10.1007/s11684-013-0285-z
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
《医学前沿(英文)》 2023年 第17卷 第1期 页码 143-155 doi: 10.1007/s11684-022-0929-y
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in
《医学前沿(英文)》 2022年 第16卷 第5期 页码 808-814 doi: 10.1007/s11684-021-0878-x
关键词: epidermolysis bullosa LAMA3 COL7A1 KRT5 Chinese families
Wenjie Zhu, Binghe Xu
《医学前沿(英文)》 2021年 第15卷 第2期 页码 208-220 doi: 10.1007/s11684-020-0795-4
关键词: endocrine-resistant HR+/HER2- advanced breast cancer randomized clinical trials meta-analysis targeted therapy
标题 作者 时间 类型 操作
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
期刊论文
单萜类化合物芳樟醇、甲基丁香酚、草蒿脑和香茅醛对配体门控离子通道的作用模式
Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen
期刊论文
Resistance of large deformation of the Wushaoling Tunnel F7 soft fault
ZHAO Xufeng, CHEN Haiming, WANG Chunmiao
期刊论文
Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A
期刊论文
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
期刊论文
A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO
Jing DONG, Huilong WANG
期刊论文
Erratum to “After Highflyer Crashes, Airborne Wind Energy Regroups” [Engineering 7 (2021) 277–279]
Peter Weiss
期刊论文
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
null
期刊论文
Universal influenza virus vaccines: what can we learn from the human immune response following exposure to H7
null
期刊论文
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in
期刊论文